Spectrum: Local Antimicrobial Stewardship, for Providence Health Care

Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

2 g IV q8h

General Information

Common Usage

Common Usage

Skin and soft tissue infection (i.e. cellulitis), bone and joint infections, endocarditis

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and Gram negative infections.

Adverse Effects

Adverse Effects

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Major Interactions

Major Interactions

Probenecid prolongs half-life. Drug interaction has been used therapeutically to give once daily cefazolin

Pharmacology

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic