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Guidelines
Pathogens
Antimicrobials
Medium
Excellent
875mg PO BID or 500mg PO TID of the amoxicillin component
Prophylaxis/treatment of bite wounds
Polymicrobial infections of the respiratory tract or abdomen
Skin and soft tissue infections
For prolonged therapy monitor liver enzymes, CBC
Hepatotoxicity due to calvulanate- usually mild, liver failure is rare
Allergy/rash (immediate or delayed), cytopenias, diarrhea. Note EBV related rash
Increased risk of rash with allopurinol
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Pregnancy category: B
Average serum half life: 1.0
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic