Spectrum: Local Antimicrobial Stewardship, for Providence Health Care

Rifampin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Information

Common Usage

Common Usage

  • Mycobacterial infections

  • Brucellosis

  • Osteomyelitis

  • Prosthetic joint infections due to Staphyloccocus aureus (always use in combination with other agents).

Drug Monitoring

Drug Monitoring

Lab

  • Basline and periodic LFTs

Clinical

  • Multiple drug interactions

Adverse Effects

Adverse Effects

  • Nausea/vomiting, diarrhea

  • Abnormal liver enzymes

  • Rash (Steven-Johnson syndrome)

  • Myopathy

Major Interactions

Major Interactions

Inducer of many CYP enzymes including 3A4, and 2C9.

Anticoagulants and anticonvulsants are among those affected but list of interacting drugs is large.

A Pharmacy consult is recommended when initiating rifampin therapy.

Pharmacology

Pharmacology

Antimicrobial class: Antimycobacterial

Pregnancy category: C

Average serum half life: 3-4 hr

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Route of Elimination: Feces