Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Tigecycline

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

Loading dose: 100mg IV x1 dose
Maintenance dose: 50mg IV q12h

Hepatic

Adjustments required for severe hepatic impairment (Child Pugh C)

General Information

Acceptable Uses

Brand Name

Tygacil

Unacceptable Uses

Unacceptable Uses

Avoid in bacteremia due to low blood concentrations

Adverse Effects

Adverse Effects

  • GI upset

  • Severe nausea

  • Vomiting

  • Increased LFTs

Pharmacology

Pharmacology

Pharmacology: Inhibits protein synthesis

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 42 hours

Urine penetration: Poor