Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Linezolid

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

600mg IV/PO q12h

General Information

Acceptable Uses

Brand Name

Zyvox

Adverse Effects

Adverse Effects

  • Thrombocytopenia

  • Anemia, neutropenia

Rare

  • Neuropathies

  • Optic neuritis

  • Mitochondrial toxicities

Major Interactions

Major Interactions

Increased risk for serotonin syndrome when used with other serotenergic agents

Oral Liquids

Oral Liquids

100mg/5mL suspension

Tablet/Capsule Strengths

Tablet/Capsule Strengths

600mg tablet

Pharmacology

Pharmacology

Pharmacology: Protein synthesis inhibitor

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5 hours

CSF penetration: Good

Route of Elimination: Partial renal