Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Amoxicillin-Clavulanate

Oral Bioavailability

Moderate

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

875-125mg PO BID
or
500-125mg PO BID

Renal

Renal adjustments required when CrCL < 30 mL/min

General Information

Acceptable Uses

Brand Name

Augmentin

Adverse Effects

Adverse Effects

  • Diarrhea

  • GI upset

  • Nausea

Oral Liquids

Oral Liquids

  • 200-28.5mg/5mL suspension

  • 250-62.5mg/5mL suspension

  • 400-57mg/5mL suspension

  • 600-42.9mg/5mL suspension

Tablet/Capsule Strengths

Tablet/Capsule Strengths

  • 250-125mg tablet

  • 500-125mg tablet

  • 875-125mg tablet

Pharmacology

Pharmacology

Pharmacology: Inhibits cell wall synthesis

Antimicrobial class: Beta-lactam

  • Aminopenicillin and beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Route of Elimination: Renal