Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Nitrofurantoin

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

100mg PO q12h

Renal

Do not use when CrCl < 60 mL/min

General Information

Acceptable Uses

Brand Name

Macrobid

Adverse Effects

Adverse Effects

  • Nausea

  • Urine discoloration (brown)

Rare

  • Pulmonary toxicity

  • Peripheral neuropathies

  • Hemolytic anemia

Oral Liquids

Oral Liquids

25mg/5mL suspension

Tablet/Capsule Strengths

Tablet/Capsule Strengths

  • 25mg capsule

  • 50mg capsule

  • 100mg capsule

Pharmacology

Pharmacology

Pharmacology: Inhibits DNA synthesis

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1 hour

Route of Elimination: Renal