Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Levofloxacin

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

500-750mg IV/PO q24h

Renal

Renal adjustments required when CrCl < 50 mL/min

General Information

Acceptable Uses

Brand Name

Levaquin

Adverse Effects

Adverse Effects

  • GI upset

  • C. diff

  • Photosensitivity

  • Altered mental status (elderly)

  • Prolonged QTc

  • Hyperglycemia

Rare

  • Tendon rupture (black box warning)

Major Interactions

Major Interactions

Do not take with divalent cations

Oral Liquids

Oral Liquids

25mg/1mL solution

Tablet/Capsule Strengths

Tablet/Capsule Strengths

  • 250mg tablet

  • 500mg tablet

  • 750mg tablet

Pharmacology

Pharmacology

Pharmacology: Inhibits DNA topoisomerase

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Route of Elimination: Renal