Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Imipenem-Cilastatin

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

500mg IV q6h

Renal

Renal adjustments required when CrCl < 60 mL/min

General Information

Acceptable Uses

Brand Name

Primaxin

Adverse Effects

Adverse Effects

Rare

  • Seizures

  • Cytopenias

  • AIN

Additional Information

Additional Information

Cilastatin - renal DHP inhibitor

Pharmacology

Pharmacology

Pharmacology: Inhibits cell wall synthesis

Antimicrobial class: Beta-lactam

  • Carbapenem

Average serum half life: 1 hour

Metabolism: Imipenem - renal dehydropeptidase

Route of Elimination: Renal