Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Piperacillin-Tazobactam

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

3.375-4.5g IV q6h
3.375g IV q8h (infused over 4 hours)

Renal

Renal adjustments required when CrCl < 20 mL/min

General Information

Acceptable Uses

Brand Name

Zosyn

Adverse Effects

Adverse Effects

  • GI upset

  • Nephrotoxicty (when used with vancomycin)

Rare

  • Thrombocytopenia

  • AIN

Pharmacology

Pharmacology

Pharmacology: Inhibits cell wall synthesis

Antimicrobial class: Beta-lactam

  • Ureidopenicillin and beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

CSF penetration: Poor

Route of Elimination: Renal