Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Ciprofloxacin

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Renal

Renal adjustments required when CrCl < 30 mL/min

General Information

Acceptable Uses

Brand Name

Cipro

Adverse Effects

Adverse Effects

  • GI upset

  • Diarrhea

  • C. difficile

  • Photosensitivity

  • Altered mental status (elderly)

  • Hyperglycemia

Rare

  • Tendon rupture (black box warning)

Major Interactions

Major Interactions

Do not administer with divalent cations

Oral Liquids

Oral Liquids

  • 250mg/5mL suspension

  • 500mg/5mL suspension

Tablet/Capsule Strengths

Tablet/Capsule Strengths

  • 100mg tablet

  • 250mg tablet

  • 500mg tablet

  • 750mg tablet

Pharmacology

Pharmacology

Pharmacology: Inhibits DNA topoisomerase

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Route of Elimination: Renal