Excellent
Rash
GI upset
Nausea
Renal dysfunction (worse with IV)
Hyperkalemia (worse with IV)
Rare
Stevens-Johnson syndrome
Bone marrow suppression (worse with IV)
IV solution requires large fluid volumes.
Drug of choice for Pneumocystis jirovecii pneumonia
Pharmacology: Inhibits folic acid synthesis
Antimicrobial class: Sulfonamide - DHFR inhibitor
Pregnancy category: C
Average serum half life: 10 hours
Route of Elimination: Renal
Metabolism: Partial hepatic
