Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Ampicillin-Sulbactam

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

3g IV q6h

Renal

Renal adjustments required when CrCl < 50 mL/min

General Information

Acceptable Uses

Brand Name

Unasyn

Adverse Effects

Adverse Effects

  • Rash

  • GI upset

Rare

  • C difficile diarrhea

Pharmacology

Pharmacology

Pharmacology: Inhibits cell wall synthesis

Antimicrobial class: Beta-lactam

  • Aminopenicillin + beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

CSF penetration: Poor

Route of Elimination: Renal