Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Ceftolozane-Tazobactam

Oral Bioavailability

NA

Approximate Cost

$$$

Dosing

Adult

1.5 - 3g IV q8h

Renal

Renal adjustments required when CrCl < 50mL/min

General Information

Acceptable Uses

Brand Name

Zerbaxa

Adverse Effects

Adverse Effects

  • GI upset

  • Diarrhea

Rare

  • C difficile diarrhea

Additional Information

Additional Information

Primarily reserved for multi-drug Pseudomonas aeruginosa

Pharmacology

Pharmacology

Pharmacology: Cell wall synthesis inhibitor

Antimicrobial class: Beta-lactam

  • ? generation cephalosporin + tazobactam

Pregnancy category: B

Average serum half life: 2 - 3 hours (ceftolozane)
1 - 2 hours (tazobactam)

Route of Elimination: Renal