Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Daptomycin

Oral Bioavailability

NA

Approximate Cost

$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

4-6mg/kg IV q24h (SSTI, UTI)
8-10mg/kg IV q24h (non-SSTI, UTI)

Renal

Renal adjustments required when CrCl < 30 mL/min

General Information

Acceptable Uses

Brand Name

Cubicin

Drug Monitoring

Drug Monitoring

CPK (creatine phosphokinase)

Adverse Effects

Adverse Effects

  • Increased CPK

  • Myopathy

Rare

  • Rhabdomyolysis

  • Eosinophilic pneumonia

Major Interactions

Major Interactions

Statins

Pharmacology

Pharmacology

Pharmacology: Depolarizes cell membrane

Antimicrobial class: Cyclic lipopeptide

Pregnancy category: B

Average serum half life: 9 hours

Lung penetration: Poor

Route of Elimination: Renal