Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Amikacin

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

15 mg/kg IV q24h

Renal

Renal adjustments required

General Information

Acceptable Uses

Brand Name

Amikin

Adverse Effects

Adverse Effects

  • Nephrotoxicity (reversible)

  • Auditory and vestibular toxicity (irreversible)

  • Neuromuscular blockade

Additional Information

Additional Information

Use Hartford nomogram for interval adjustments

Pharmacology

Pharmacology

Pharmacology: Inhibits protein synthesis

Antimicrobial class: Aminoglycoside

Pregnancy category: D

Average serum half life: 2 - 3 hours

CSF penetration: Poor

Route of Elimination: Renal