Spectrum: Local Antimicrobial Stewardship, for Chapman University School of Pharmacy

Minocycline

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

Loading dose: 200mg x1
Maintenance dose: 100mg IV/PO q12h

General Information

Acceptable Uses

Brand Name

Minocin

Adverse Effects

Adverse Effects

  • Photosensitivity

  • Teeth staining (<8 years of age)

  • GI upset

  • Vertigo

Rare

  • Hepatotoxicity

  • Esophageal ulceration

Major Interactions

Major Interactions

Avoid taking with divalent cations if possible.

Tablet/Capsule Strengths

Tablet/Capsule Strengths

  • 50mg tablet/capsule

  • 75mg tablet/capsule

  • 100mg tablet/capsule

Pharmacology

Pharmacology

Pharmacology: Inhibits protein synthesis

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 16 hours

Urine penetration: Poor

CSF penetration: Poor

Route of Elimination: Renal

Metabolism: Hepatic