Spectrum: Local Antimicrobial Stewardship, for Prisma Health-Midlands

Vancomycin PO

C. diff Risk

NA

Oral Bioavailability

None

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

125mg po/ng/og q6h for 10-14 days.

Intra-colonic dose 500mg in 100mL of NS by rectal enema q6h

General Information

Acceptable Uses

Appropriate Use

Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.

Approved Indications:

  1. PRE-OP Dose
  2. Bacteremia [Severe]
  3. Endocarditis [Severe]
  4. Meningitis, Community-onset [Severe]
  5. Meningitis, Hospital-onset [Severe]
  6. Neutropenic fever [Severe]
  7. Osteomyelitis [Severe]
  8. Pneumonia [Severe]
  9. Sepsis (e.g. qSOFA >2) [Severe]
  10. SSTI –Necrotizing fasciitis [Severe]
  11. SSTI –Comp cellulitis/abscess [Moderate]
  12. SSTI –Uncomp cellulitis/abscess [Mild]
  13. Urinary tract infection [Mild]
  14. Clostridium difficile

Common Usage

Common Usage

Only indication is in the therapy of C. difficile infection, particularly recurrent or severe disease

Drug Monitoring

Drug Monitoring

Possibility of accumulation in severe renal dysfunction.

Consider checking a vancomycin level in dialysis patients.

Additional Information

Additional Information

No oral absorption.

May increase vancomycin resistant Enterococci colonization in the gut.

Pharmacology

Pharmacology

Antimicrobial class: Glycopeptide

Pregnancy category: B

Average serum half life: 0 hours

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: None