Spectrum: Local Antimicrobial Stewardship, for Prisma Health-Midlands

Meropenem

Restricted
Restricted

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

Standard Dose 500mg IV q6h or 1g IV q8h

Meningitis 2g IV q8h

Renal

General Information

Acceptable Uses

Appropriate Use

Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.

Approved Indications:

  1. Documented infection with P.aeruginosa
  2. Penicillin AND cephalosporin allergies
  3. High suspicion for ESBLs or P.aeruginosa
  4. Peds ONLY - Hemodynamically unstable
  5. Peds ONLY - Fever/neutropenia & typhlitis
  6. Peds ONLY - Suspected NEC - severe

Common Usage

Common Usage

Therapy of serious, often nosocomial infections involving resistant gram negative organisms.

Adverse Effects

Adverse Effects

  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, positive Coombs

  • Liver enzyme abnormalities

Major Interactions

Major Interactions

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold.

Pharmacology

Pharmacology

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic