Spectrum: Local Antimicrobial Stewardship, for Prisma Health-Midlands

Cefuroxime

C. diff Risk

High

Oral Bioavailability

Moderate

Approximate Cost

$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

750-1500mg IV q8h

500mg PO q12h

Renal

General Information

Common Usage

Common Usage

  • Community acquired pneumonia with a macrolide

  • Intraabdominal infection

  • Epiglottitis

Adverse Effects

Adverse Effects

  • Allergy (immediate & delayed)

  • Positive Coombs

  • Cytopenias

  • GI upset

  • Diarrhea

  • Abnormal liver enzymes

Major Interactions

Major Interactions

No significant interactions.

Pharmacology

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic