Spectrum: Local Antimicrobial Stewardship, for Prisma Health-Midlands

Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

2g IV q8h (max 6 gm/day)

Renal

General Information

Common Usage

Common Usage

Skin and soft tissue infection (e.g. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and gram negative infections.

Adverse Effects

Adverse Effects

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Major Interactions

Major Interactions

Probenecid - prolonged half-life.

Drug interaction has been used therapeutically to give once daily cefazolin.

Not recommended unless no other alternatives.

Pharmacology

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic