Spectrum: Local Antimicrobial Stewardship, for Prisma Health-Midlands

Aztreonam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$$$$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

2g IV q8h for severe infections

Renal

General Information

Common Usage

Common Usage

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent.

Nebulized form used in cystic fibrosis patients.

Empiric therapy for febrile neutropenia.

Drug Monitoring

Drug Monitoring

Monitor liver enzymes

Adverse Effects

Adverse Effects

  • Elevated liver enzymes

  • Cytopenias

  • Eosinophilia

  • Phlebitis at injection site

  • Rash/allergy

  • CNS toxicity

Major Interactions

Major Interactions

No significant interactions.

Pharmacology

Pharmacology

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic