Spectrum: Local Antimicrobial Stewardship, for Island Health

Colistin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

Dosed in colistin base:

Critically Ill
300 mg IV load, then 150 mg IV q12h or 2.5-5 mg IV daily (divided q12h)

Cystic Fibrosis
3 mg/kg/day in 3 divided doses

Renal

General Information

Common Usage

Common Usage

Infections caused by Carbapenemase-producing organisms.

Drug Monitoring

Drug Monitoring

Renal function

Adverse Effects

Adverse Effects

  • Acute renal failure

  • Muscle weakness

  • Paresthesias

  • Slurred speech

  • Vertigo

Major Interactions

Major Interactions

Nephrotoxins.

Concurrent use or pre-administration of other neuromuscular blocking agents, which can interfere with neuromuscular function.

Additional Information

Additional Information

Avoid in myasthenia gravis.

Pharmacology

Pharmacology

Antimicrobial class: cationic detergent

Average serum half life: 2.5 hours

CSF penetration: No