Spectrum: Local Antimicrobial Stewardship, for Island Health

Penicillin G

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

IV-$20/d

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Adult

12-24 million units/day IV in 6 divided doses

Renal

General Information

Common Usage

Common Usage

Therapy of Streptococcal and other documented susceptible infections, syphilis

Adverse Effects

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Pharmacology

Pharmacology

Antimicrobial class: penicillin

Pregnancy category: B

Average serum half life: 1.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic