Spectrum: Local Antimicrobial Stewardship, for Island Health

Fidaxomicin

Restricted
Restricted

C. diff Risk

None

Oral Bioavailability

None

Approximate Cost

$200/day+

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

200mg po BID x 10 days for C. difficile

General Information

Common Usage

Common Usage

C. difficile colitis

Drug Monitoring

Drug Monitoring

None

Adverse Effects

Adverse Effects

  •  GI disturbance

  •  Cytopenias

  •  Hypersensitivity: facial, tongue or throat swelling

Additional Information

Additional Information

Consult Infectious Disease.

Non-formulary - therefore will require approval.

Use with caution in patients with history of macrolide allergy - may have increased risk of hypersensitivity.

Pharmacology

Pharmacology

Antimicrobial class: Specialized anti-C. diffile macrocyclic agent

Pregnancy category: B

Average serum half life: 0.0

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: None