Spectrum: Local Antimicrobial Stewardship, for Island Health

Daptomycin

Restricted
Restricted

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$150/day+

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Adult

Endocarditis or bloodstream infection
6-12 mg/kg IV daily

Non-bloodstream infections
4-6 mg/kg IV daily

Hepatic

Unknown for severe hepatic dysfunction

Renal

General Information

Common Usage

Common Usage

Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC>=2) and VRE including endovascular infection

Drug Monitoring

Drug Monitoring

Creatine kinase weekly

Adverse Effects

Adverse Effects

  • GI side effects common

  • Rash

  • Phlebitis

  • Increased INR

  • Myopathy including rhabdomyolysis

Major Interactions

Major Interactions

Statins and fibrates: monitor creatine kinase or hold while on daptomycin therapy (increased myopathy)

Additional Information

Additional Information

Restricted to ID or Medical Microbiology. Please consult.

Pharmacology

Pharmacology

Antimicrobial class: Cyclic lipopeptide, depolarizes bacterial cell membrane

Pregnancy category: B

Average serum half life: 9.0

CSF penetration: Poor

Lung penetration: Poor

Urine penetration: Therapeutic