Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Culture Negative Endocarditis

Recommended Treatment

Ampicillin-sulbactam 200-300 mg/kg/day (Max. 12g) IV every 4-6hrs

AND

Gentamicin 3-6 mg/kg/day IV every 8hrs

OR

Vancomycin 40 mg/kg/day (Max. 2g)

Recommended only for patients who are unable to tolerate penicillins

AND

Gentamicin 3-6 mg/kg/day IV every 8hrs

AND

Ciproflaxacin 20-30 mg/kg/day IV/PO every 12hrs