Major Criteria | Spectrum

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Two positive blood cultures growing typical organisms, such as Streptococcus viridans and the HACEK* group

*HACEK group: Haemophilus spp., Actinobacilius actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae

Persistent bacteraemia: ≥2 blood cultures taken >12 hours apart or ≥3 positive blood cultures, such as Staphylococcus aureus and Staphylococcal epidermidis

Positive serology for Coxiella burnetti, Bartonella species, or Chlamydia psittaci OR positive molecular assays for specific gene targets

Positive echocardiogram showing vegetation(s), abscess formation, new valvular regurgitation, or dehiscence of prosthetic valves