Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Dihydroartemisinin + Piperaquine

Treatment

Dihydroartemisinin 20mg tablet

AND

Piperaquine 160mg tablet

OR

Dihydroartemisinin 20mg

COMBINED IN A TABLET WITH

Piperaquine 160mg

Combined tablet should be given od for 3 days

Dosing for Separate Tablets

Body Weight of <25kg:

  • Dihydroartemisinin 2.5 mg/kg od

  • Piperaquine 20 mg/kg od

Body Weight of ≥25kg:

  • Dihydroartemisinin 4 mg/kg od

  • Piperaquine 24 mg/kg od

Duration of Therapy

3 days

Notes

For infants <5kg, ACT target dose the same mg/kg body weight as for children weighing 5kg

Target dose (for body weight ≥25kg):

  • 2.5-10 mg/kg Dihydroartemisinin od for 3 days

  • 20-32 mg/kg Piperaquine od for 3 days