MSSA:

• Anti-staphylococcal penicillins (i.e. cloxacillin) and cephalosporins (i.e. cefazolin) are optimal agents for intravenous therapy of MSSA infections

• Variable susceptibility to TMP-SMX, Clindamycin, and Tetracyclines

MRSA:

• By definition resistant to cloxacillin and cephalosporins

• Susceptible to vancomycin, daptomycin, and linezolid

• Variable susceptibility to TMP-SMX, Clindamycin, and Tetracyclines