Humans are the reservoir - fecal-oral transmission.
Increased prevalence in developing countries.
Highest prevalence South Asia
Enteric fever
FUO
Bacteremia
Intra-abdominal abscess
Meningitis
Endovascular infection including endocarditis
Very high rates of FQ resistance in Southeast Asia
Vaccine is available
Chronic carriage associated with gallbladder disease ("Typhoid Mary")
