NA
Excellent
Severe malariaIntravenous quinine infusion; loading dose of 20 mg/kg (given over 4 hours) at admission then 10 mg/kg (given over 2 hours) every 8 hours. Reduce dose by one third in severe malaria after 48 hours if no clinical improvement.
Uncomplicated malaria10 mg salt/kg three times a day (30 mg salt/kg/d) for 7 days
Alternative treatment for severe malaria (if artesunate is not available).
Oral preparation sometimes used to treat uncomplicated malaria as an alternative to artemisinin-based combination therapies.
Pregnancy category: Used in the first trimester of pregnancy to treat uncomplicated falciparum malaria (combined with clindamycin)
Average serum half life: 9 to 18 hours
Metabolism: Quinine undergoes hepatic biotransformation to 3-hydroxyquinine and dihydroquinine. Unchanged drug is excreted via the kidney. Metabolism to the biologically active 3-hydroxyquinine increases with recovery from acute malaria.
