Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Amodiaquine

C. diff Risk

NA

Oral Bioavailability

Excellent

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Neonatal

Not licensed for use in infants weighing less than 4.5 kg, however WHO recommends it may still be given, targeting the same mg/kg dose.

Adult

10 mg/kg/day amodiaquine once a day for 3 days given with 4 mg/kg/day artesunate

General Information

Adverse Effects

Adverse Effects

N/a

Major Interactions

Major Interactions

Coadministration with zidovudine is associated with high rates of neutropenia.

Nevirapine-containing ART regimens are associated with reduced amodiaquine exposure.

Efavirenz coadministered with amodiaquine has been associated with hepatotoxicity.

Pharmacology

Pharmacology

Antimicrobial class: 4-aminoquinoline

Average serum half life: Approximately 9 days in children with malaria

Metabolism: Rapid first-pass hepatic metabolism to the biologically active metabolite desethylamodiaquine (DeAQ) mediated by cytochrome P450 (CYP2C8).