Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Piperacillin-Tazobactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$30/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Pediatric

*IE: 240 mg/kg/day IV q8h

Adult

Preferred Dosing:
3 grams* IV q6h

*Injection 3/ 0.375 g vial containing: 3 g piperacillin and 0.375 g tazobactam

OR
Alternate Dosing:
4 grams* IV q8h

*Injection 4/ 0.5 g vial containing: 4 g piperacillin and 0.5 g tazobactam

General Information

Common Usage

Common Usage

Broad spectrum agent with anti-pseudomonal activity used for severe infections including:

  • Pneumonia

  • Intra-abdominal/hepatobiliary

  • Polymicrobial skin and soft tissue infection

  • Febrile neutropenia

Drug Monitoring

Drug Monitoring

  • Renal and hepatic function

  • CBC with differential

  • C. difficile-associated diarrhea

  • Hypersensitivity reactions

Adverse Effects

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias- esp. thrombocytopenia, eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes