Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Doxycycline

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$0.20/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Pediatric

Filariasis100-200mg PO OD x 6-8 wks

Leptospirosis200mg PO OD, wkly

Cholera4.4 mg/kg/day IV STAT

Adult

100 mg PO q12h

General Information

Common Usage

Common Usage

  • Lyme disease

  • Skin and soft tissue infection

  • Methicillin resistant staphylococcus aureus infections

Adverse Effects

Adverse Effects

  • GI upset (take with food to avoid)

  • Erosive esophagitis (drink plenty of water with dose)

  • Photosensitivity rash

  • Teeth staining (risk much lower than with other tetracyclines)

Major Interactions

Major Interactions

Divalent cations- decreased absorption therefore recommended to space by 2 hours.

Additional Information

Additional Information

Take with food to reduce GI upset.
Avoid iron, magnesium, calcium for at least two hours before or two hours after doxycycline administration.

Contraindicated in pregnancy and not routinely recommended in children <8 years of age due to risk for tooth enamel hypoplasia and permanent discolouration of the developing teeth (much lower than other tetracyclines)

Pharmacology

Pharmacology

Antimicrobial class: Tetracycline

Average serum half life:

  • No data for pediatrics.

  • Adults: 12 to 15 hours (usually increases to 22 to 24 hours with multiple dosing)

Route of Elimination: In the urine (23%) and feces (30%)