Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Penicillin G (parenteral)

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

IV-$20/d

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Pediatric

Leptospirosis1 L/kg IV q4h x 7 days

Severe pneumonia0.5 L/kg IV q6h x 5 days

IE2-3 L/kg/day IV q4h

Adult

5 million units IV once, then 2.5 million units IV q4h until delivery

General Information

Common Usage

Common Usage

  • Therapy of Streptococcal and other documented susceptible infections

  • Syphilis

Drug Monitoring

Drug Monitoring

Renal and hepatic function, CBC with differential, hypersensitivity reactions and IV site for phlebitis.

Adverse Effects

Adverse Effects

Allergy/rash (immediate or delayed), seizures, cytopenias, eosinophilia, interstitial nephritis, abnormal liver enzymes, serum sickness

Pharmacology

Pharmacology

Antimicrobial class: Penicillin

Average serum half life:
Neonates:

  • <6 days: 3.2 to 3.4 hours

  • 7 to 13 days: 1.2 to 2.2 hours

  • >14 days: 0.9 to 1.9 hours.

Pediatrics: 0.5-1.2 hours.
Adults normal renal function: 30- 50 minutes

Route of Elimination: Renal (58% to 85% unchanged drug)