Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$0.50/day

Spectrum Of Activity

Dosing

20-30 mg/kg/24h PO divided q12h

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Enteric fever75-100 mg/kg/day PO q8h x 14 days

Salmonella GE40-50 mg/kg/day PO q8h x 5 days

UTI10-25 mg/kg/dose PO q8h

Pneumonia40 mg/kg/dose PO BD x 5 days

500 mg PO q8h (Urinary tract infection)
1000 mg PO q8h (Community acquired pneumonia in pregnancy)

General Information

Common Usage

Therapy of streptococcal, enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and urinary tract infection (when organisms susceptible)

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Cytopenias

  • EBV related rash (not allergy)

Pharmacology

Antimicrobial class: Aminopenicillin

Average serum half life: Neonates, full-term: 3.7 hours
Infants and children: 1 to 2 hours

Route of Elimination: Renal excretion (60% unchanged drug)