Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Cloxacillin

C. diff Risk

Medium

Oral Bioavailability

None

Approximate Cost

$10/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Neonatal

Other

For oral therapy: consider oral cephalexin as alternative as oral cloxacillin is poorly absorbed and must be administered on an empty stomach in frequent doses.

Pediatric

Pleural empyema50 mg/kg/dose IV q6h x 1-4 wks

IE50 mg/kg/dose IV q6h x 4-6 wks

General Information

Common Usage

Common Usage

Treatment of sensitive MSSA and CoNS infections

Drug Monitoring

Drug Monitoring

  • Renal and hepatic function

  • CBC with differential

  • Diarrhea

Adverse Effects

Adverse Effects

  • Allergy (immediate or delayed)

  • Phlebitis (IV)

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Pharmacology

Pharmacology

Antimicrobial class: Antistaphylococcal penicillin

Average serum half life: Adults: 0.5-1.5 h (prolonged in renal impairment and in neonates)

Route of Elimination: Urine and feces