Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

IV-15$

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

Dosing

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Pediatric

Severe pneumonia50 mg/kg/dose PO q8h x 3-5 days

UTI10-15 mg/kg/dose PO q12-24h

General Information

Common Usage

Common Usage

Community acquired lower respiratory tract infections.

Adverse Effects

Adverse Effects

  • Allergy (immediate & delayed)

  • Positive Coombs

  • Cytopenias

  • GI upset, diarrhea

  • Abnormal liver enzymes

Pharmacology

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Average serum half life: Pediatrics: 1.4-1.9 hours.

Route of Elimination: 66-100% as unchanged drug in urine by both glomerular filtration and tubular secretion