Medium
Excellent
IV-$9/d PO-$1/d
Enteric fever10-20 mg/kg/day PO 7-10 days
Cholera10 mg/kg/day PO OD x 3 days
Campylobacter dysentery4-7 mg/kg/day IV BD x 5 days
500 mg/dose PO x 1 dose on Day 1
then 250 mg/dose PO q24h on Days 2-5
500 mg/dose IV q24h for 2 days then switch to oral therapy
Community acquired pneumonia, Pertussis, upper respiratory tract infections, Chlamydial infections, mycobacterial infections
Prolongation of QTc interval.
One study suggested that there is 3-8 fold risk of pyloric stenosis with use of azithromycin in neonates. Therefore clinicians need to weigh benefits and risks when considering whether to use azithromycin in young infants.
While less risk of interaction compared to other macrolides, several potential CYP450 interactions may occur; consult a pharmacist for for more details.
Avoid concurrent use with other drugs that prolong QTc
Antimicrobial class: Macrolide
Average serum half life: Pediatrics: 54.5 hours
Route of Elimination: 50% excreted unchanged in bile.
6-14% excreted unchanged in urine.
