Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Ceftazidime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$18/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Neonatal

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Pediatric

Severe pneumonia50 mg/kg/dose IV q8h

IE50 mg/kg/dose IV q8h x 4-6 wks

General Information

Common Usage

Common Usage

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins

Adverse Effects

Adverse Effects

Allergy (immediate and delayed)

Pharmacology

Pharmacology

Antimicrobial class: 3rd generation Cephalosporin

Average serum half life:

  • Neonates <23 days: 2.2-4.7 hours

  • Adults: 1-2 hours

Route of Elimination: By glomerular filtration with 80-90% of dose excreted as unchanged drug in urine within 24 hours.