Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Erythromycin

C. diff Risk

None

Oral Bioavailability

Moderate

Approximate Cost

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Neonatal

Renal

Reduce dose in renal impairment or need for caution.

Other

Erythromycin use has been associated with an increased risk of hypertrophic pyloric stenosis in term infants less than 14 days of age.

Pediatric

Campylobacter dysentery30-50 mg/kg/day PO q12h x 5 days

Rheumatic fever prophylaxis250mg PO q12h

Streptococci250mg PO q6h x 10 days

Adult

250 -500 mg PO q6h

General Information

Common Usage

Common Usage

Pertussis, Chlamydial infections, mycobacterial infections, latency in pregnancy

Drug Monitoring

Drug Monitoring

Monitor QTc in patients with increased risk.

Adverse Effects

Adverse Effects

  • GI upset, diarrhea

  • Prolongation of QTc interval

Major Interactions

Major Interactions

Substrate of CYP3A4. Multiple CYP450 interactions possible - consult a pharmacist for more detail. May increase digoxin, carbamazepine level. Caution with QTc prolonging medications

Additional Information

Additional Information

Erythromycin use has been associated with an increased risk of hypertrophic pyloric stenosis in term infants less than 14 days of age.

Pharmacology

Pharmacology

Antimicrobial class: Macrolide

Route of Elimination: Primarily hepatic