Spectrum: Local Antimicrobial Stewardship, for Yangon Children's Hospital

Amoxicillin-Clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Approximate Cost

$2/day

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Neonatal

30 mg/kg/24h PO divided q12h
(Dosing is based on amoxicillin component -use 25 mg/mL 4:1 ratio formulation)

Renal

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Pediatric

UTI, Pleural empyema, Severe pneumonia: 25-50 mg/kg/dose IV/PO q8h

General Information

Common Usage

Common Usage

Prophylaxis and treatment of bite wounds

Polymicrobial infections of the respiratory tract or abdomen

Skin and soft tissue infections

Adverse Effects

Adverse Effects

  • Diarrhea (common)

  • Allergy/rash

  • Cytopenias

  • Hepatotoxicity due to clavulanate is usually mild

  • EBV related rash (not allergy)

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Average serum half life: Adults: ~1 hour. Amoxicillin pharmacokinetics are not affected by clavulanic acid

Route of Elimination: Urine (amoxicillin 50% to 70% unchanged drug; clavulanic acid 25% to 40% unchanged drug)