Management | Spectrum

Note

Antibiotics should generally be withheld in hemodynamically stable patients with or without fever and no other clear source of infection pending the results of blood cultures.

Exceptions include immunocompromised or critically ill patients, patients with valve replacement or other hardware in place, or instances where there is purulence at the catheter site.

Empiric Treatment - Immunocompromised or Critically Ill Patients

Vancomycin (Dosing per pharmacy)

AND

Pip/Tazo 3.375g IV q6h.

If patient is critically ill - consider addition of aminoglycoside therapy while awaiting preliminary blood culture results.

Penicillin Allergy

Vancomycin (Dosing per pharmacy)

AND

Ciprofloxacin 400 mg IV q12h OR 750 mg PO BID

If patient is critically ill - consider addition of aminoglycoside therapy while awaiting preliminary blood culture results.

Empiric Treatment: Gram+ Clusters in 2 or More Sets of Blood Cultures

Vancomycin (Dosing per pharmacy)