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Patients with synovial fluid crystals may still have concomitant septic arthritis.
Progressively higher synovial WBC count increases the likelihood ratio (LR) of septic arthritis:
Synovial WBC count > 50 X109/L has a positive LR of 7.7 for septic arthritis
Synovial WBC count >100 X109/L has a positive LR of 28.0 for septic arthritis
PMN cell count of >90% has a positive LR of 3.4 for septic arthritis
Initial Empiric Antibiotics