The majority of coagulase-negative Staphylococci will be resistant to cloxacillin and cefazolin but susceptible to vancomycin.

While the isolation of coagulase-negative Staphylococci is often a contaminant, they have potential to cause deep-seated infections especially in the presence of prosthetic devices. Empiric therapy for true infections pending susceptibilities is vancomycin.

Isolation of Staphylococcus lugdunensis from blood cultures is associated with infective endocarditis and should be treated similarly to Staphylococcus aureus bacteremia.