While pan-susceptible E. coli strains remain, highly resistant strains such as ESBL producing organisms are increasingly prevalent.
"Pansusceptible" isolates are sensitive to:
Ampicillin
Cephalosporins including first generation cephalosporins
TMP-SMX
Fluoroquinolones
Piperacillin-tazobactam
In cases of infections due to ESBL producing organisms, carbapenems may be preferred.
Fosfomycin and nitrofurantoin should be used for cystitis only.