Spectrum: Local Antimicrobial Stewardship, for Saskatchewan Health Authority - Saskatoon Area

Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Moderate

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

Usual dose
750-1500mg IV q8h

500mg PO BID

General Information

Common Usage

Common Usage

Cefuroxime is commonly used for community-acquired pneumonia

Adverse Effects

Adverse Effects

  •  Allergy/rash

  •  Positive Coombs test

  •  Cytopenias

  •  Gastrointestinal intolerance

  • Clostridium difficile associated diarrhea

  •  Abnormal liver enzymes

Major Interactions

Major Interactions

No significant interactions.

Pharmacology

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic