Spectrum: Local Antimicrobial Stewardship, for Saskatchewan Health Authority - Saskatoon Area

Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

500-1000mg PO TID

General Information

Common Usage

Common Usage

Amoxicillin is used in the treatment of infections due to certain Streptococcus spp. and Enterococcus spp. as well as treatment of infections due to susceptible Gram negative infections.

Commonly used for upper respiratory tract infections and urinary tract infections.

Adverse Effects

Adverse Effects

  • Allergic reactions, rash

  • Cytopenias

  • Clostridium difficile associated diarrhea

Major Interactions

Major Interactions

Allopurinol - increased frequency of rash

Additional Information

Additional Information

Patients with infectious mononucleosis secondary to EBV and given amoxicillin or ampicillin may develop a rash and this is not indicative of a true allergy.

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic