Spectrum: Local Antimicrobial Stewardship, for Saskatchewan Health Authority - Saskatoon Area

Amoxicillin-clavulanate

C. diff Risk

Medium

Oral Bioavailability

Excellent

Spectrum Of Activity

General Spectrum of Activity

Spectrum Of Activity

General Spectrum of Activity

Antibiogram Data

Dosing

Renal

Adult

875mg PO BID or 500mg PO TID of the amoxicillin component

General Information

Common Usage

Common Usage

Prophylaxis and treatment of human and animal bite wounds.

Polymicrobial infections involving the respiratory tract or abdomen.

Skin and soft tissue infections.

Drug Monitoring

Drug Monitoring

For prolonged therapy, monitor renal and hepatic function.

Adverse Effects

Adverse Effects

  • Allergy/rash

  • Cytopenias

  • Gastrointestinal intolerance

  • Clostridium difficile associated diarrhea

Major Interactions

Major Interactions

Allopurinol - increased risk of rash

Pharmacology

Pharmacology

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic